abstract：:Substance Use Disorder (SUD) is a chronic and relapsing disease characterized by craving, loss of control, tolerance and physical dependence. At present, the combination of pharmacotherapy and psychosocial intervention is the most effective management strategy in preventing relapse to reduce dropout rates and promote ...

authors： Antonelli M,Fattore L,Sestito L,Di Giuda D,Diana M,Addolorato G

更新日期：2021-03-01 00:00:00

abstract：:Research shows that there has been a substantial increase in substance use and abuse during the COVID-19 pandemic, and that substance use/abuse is a commonly reported way of coping with anxiety concerning COVID-19. Anxiety about COVID-19 is more than simply worry about infection. Research provides evidence of a COVID ...

authors： Taylor S,Paluszek MM,Rachor GS,McKay D,Asmundson GJG

更新日期：2021-03-01 00:00:00

abstract：OBJECTIVES:We explored the male-female health-survival paradox in the context of health expectancy (HE) at age 65 and thereafter, using three different morbidity measures and different severity cut-offs with and without adjustments for the share of nursing home residents. METHODS:HE at ages 65, 70, 75, 80, and 85 was ...

authors： Stephan AJ,Schwettmann L,Meisinger C,Ladwig KH,Linkohr B,Thorand B,Schulz H,Peters A,Grill E

更新日期：2021-03-01 00:00:00

abstract：:With 59 Recent species, Bursidae, known as «frog shells», are a small but widely distributed group of tropical and subtropical gastropods that are most diverse in the Indo-West Pacific. The present study is aimed at reconstructing phylogenetic relationships of bursid gastropods based on extensive and representative ta...

authors： Sanders MT,Merle D,Laurin M,Bonillo C,Puillandre N

更新日期：2021-03-01 00:00:00

abstract：:A physiologically relevant glioma tumor model is important to the study of disease progression and screening drug candidates. However, current preclinical glioma models lack the brain microenvironment, and the established tumor cell lines do not represent glioma biology and cannot be used to evaluate the therapeutic e...

authors： Zhang L,Liu F,Weygant N,Zhang J,Hu P,Qin Z,Yang J,Cheng Q,Fan F,Zeng Y,Tang Y,Li Y,Tang A,He F,Peng J,Liao W,Hu Z,Li M,Liu Z

更新日期：2021-03-01 00:00:00

abstract：:Chemical-peptide conjugation is the molecular initiating event in skin sensitization. The OECD test guideline uses a high-performance liquid chromatography/ultraviolet (HPLC/UV) detection method to quantify chemical-peptide conjugation in a direct peptide reactivity assay (DPRA), which measures the depletion of two sy...

authors： Wei Z,Fang Y,Gosztyla ML,Li AJ,Huang W,LeClair CA,Simeonov A,Tao D,Xia M

更新日期：2021-03-01 00:00:00

abstract：:Persistent activation of STAT3 and Nrf2 is considered to stimulate the aggressive behavior of basal-like breast cancer (BLBC). However, the precise mechanism underlying sustained overactivation of these transcription factors and their roles in breast cancer progression remain elusive. Analysis of the TCGA multi-omics ...

authors： Kim SJ,Saeidi S,Cho NC,Kim SH,Lee HB,Han W,Noh DY,Surh YJ

更新日期：2021-03-01 00:00:00

abstract：:Islands are separated by natural barriers that prevent gene flow between terrestrial populations and promote allopatric diversification. Birds in the South Pacific are an excellent model to explore the interplay between isolation and gene flow due to the region's numerous archipelagos and well-characterized avian comm...

authors： Mapel XM,Gyllenhaal EF,Modak TH,DeCicco LH,Naikatini A,Utzurrum RB,Seamon JO,Cibois A,Thibault JC,Sorenson MD,Moyle RG,Barrow LN,Andersen MJ

更新日期：2021-03-01 00:00:00

abstract：:Ichneumonoidea is one of the most diverse lineages of animals on the planet with >48,000 described species and many more undescribed. Parasitoid wasps of this superfamily are mostly beneficial insects that attack and kill other arthropods and are important for understanding diversification and the evolution of life hi...

authors： Sharanowski BJ,Ridenbaugh RD,Piekarski PK,Broad GR,Burke GR,Deans AR,Lemmon AR,Moriarty Lemmon EC,Diehl GJ,Whitfield JB,Hines HM

更新日期：2021-03-01 00:00:00

abstract：:Transmembrane and coiled-coil domains 1 (TMCO1) has a highly conserved amino acid sequence among species, indicating a critical role of TMCO1 in cell physiology. The deficiency of TMCO1 in humans is associated with cerebrofaciothoracic dysplasia (CFTD), glaucoma, osteogenesis and the occurrence of cancer. TMCO1 was re...

authors： Zhang N,Tang M,Wen M,Cao Y,OuYang B

更新日期：2021-03-01 00:00:00

abstract：:The four-and-a-half LIM-only protein family of transcription co-factors participates in various cellular processes, such as cell proliferation, cell differentiation, apoptosis, cell adhesion, migration, transcription and signal transduction. However, the knowledge of the structural characteristics and immune functions...

authors： Xu L,Zhou X,Wang P,Jin Q,Zhu T,Chen M,Xu H

更新日期：2021-03-01 00:00:00

abstract：:Forkhead-box O (FoxO) is the primary transcriptional effector of the insulin-like signaling pathway that enhances gluconeogenesis through transcriptional activation of PEPCK and G6Pase in mammals. We have previously demonstrated the involvement of phosphoenolpyruvate carboxykinase (BmPEPCK-2) in antiviral immunity aga...

authors： Kang X,Wang Y,Liang W,Tang X,Zhang Y,Wang L,Zhao P,Lu Z

更新日期：2021-03-01 00:00:00

abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Traditional polyherbal preparations have been utilized in Sri Lanka since ancient times and have gained a wide acceptance throughout the country. Although an extensive body of evidence supports the use of traditional herbal mixtures in the treatment of diabetes mellitus, only a few polyhe...

authors： Liyanagamage DSNK,Jayasinghe S,Attanayake AP,Karunaratne V

更新日期：2021-03-01 00:00:00

abstract：:DM9 domain containing protein (DM9CP) is a recently identified pattern recognition molecules exiting in most organisms except plants. In the present study, a novel DM9-containing protein (CgDM9CP-3) was identified from Pacific oyster Crassostrea gigas with an open reading frame of 438 bp, encoding a polypeptide of 145...

authors： Liu Y,Wang W,Zhao Q,Yuan P,Li J,Song X,Liu Z,Ding D,Wang L,Song L

更新日期：2021-03-01 00:00:00

abstract：:Cancer stem cells (CSCs) are a small subpopulation of tumor cells critical for tumor development. Their unique abilities, such as self-renewal, have resulted in tumor resistance to various cancer treatments, including traditional chemotherapy and latest immunotherapy. CSCs-targeting therapy is a promising treatment to...

authors： Shen C,Yang C,Xia B,You M

更新日期：2021-03-01 00:00:00

abstract：:The chemokine signaling axes CCR2-CCL2 and CXCR3-CXCL11 participate in the inflammatory response by recruiting leukocytes to damaged tissue or sites of infection and are, therefore, potential pharmacological targets to treat inflammatory disorders. Although multiple CCR2 orthosteric and allosteric inhibitors have been...

authors： Sommer F,Ortiz Zacarı As NV,Heitman LH,Meijer AH

更新日期：2021-03-01 00:00:00

abstract：INTRODUCTION:Efforts to understand how adolescents acquire marijuana will help to contextualize its use among youth. Little is known about ways of getting marijuana and how they differ between subgroups of adolescents. The present study sought to determine how adolescents get marijuana and if modes of access vary by so...

authors： Wagner AC,Parks MJ,Patrick ME

更新日期：2021-03-01 00:00:00

abstract：BACKGROUND:Previous studies have found that parents of children with cancer desire more prognostic information than is often given even when prognosis is poor. We explored in audio-recorded consultations the kinds of information they seek. METHODS:Ethnographic study including observation and audio recording of consult...

authors： Bluebond-Langner M,Hall N,Vincent K,Henderson EM,Russell J,Beecham E,Bryan G,Gains JE,Gaze MN,Slater O,Langner RW,Hargrave D

更新日期：2021-03-01 00:00:00

abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Pfaffia glomerata roots are widely used in Brazil to treat various pathological conditions, particularly psychological disorders. 20-hydroxyecdysone, a phytosteroid present in the plant, can promote greater body resistance against exogenous and endogenous stressors. The objective of this ...

authors： Franco RR,de Almeida Takata L,Chagas K,Justino AB,Saraiva AL,Goulart LR,de Melo Rodrigues Ávila V,Otoni WC,Espindola FS,da Silva CR

更新日期：2021-03-01 00:00:00

abstract：:Increasingly, gambling stakeholders communicate that minimizing gambling harm is a shared societal responsibility. Individual gamblers' beliefs about responsibility for minimizing gambling harm are worthy of study because these beliefs might influence gambling behavior. In this study, using a sample of casino loyalty ...

authors： Gray HM,Louderback ER,LaPlante DA,Abarbanel B,Bernhard BJ

更新日期：2021-03-01 00:00:00

abstract：BACKGROUND:Never events (NEs) are serious clinical incidents that cause potentially avoidable harm and impose a significant financial burden on healthcare systems. The purpose of this study was to identify common never events. METHODS:We analysed the NHS England NE data from 2012 to 2020 to identify common never event...

authors： Omar I,Graham Y,Singhal R,Wilson M,Madhok B,Mahawar KK

更新日期：2021-03-01 00:00:00

abstract：:Cathepsins belongs to the cysteine protease family, which are activated by an acidic environment. They play essential biological roles in the innate immunity and development of animals. Here, we identified a 62 kDa cathepsin L-like protease from the silkworm Bombyx mori. It contained putative conserved domains, includ...

authors： Sun YX,Chen C,Xu WJ,Abbas MN,Mu FF,Ding WJ,Zhang HJ,Li J

更新日期：2021-03-01 00:00:00

abstract：BACKGROUND:Complications are important indicators of immediate postoperative outcomes. The Clavien-Dindo classification (CDC) is a widely used index for the classification of surgical complications. More recently, the comprehensive complication index (CCI) has also been introduced for classifying postoperative complica...

authors： Kim SH,Hwang HK,Lee WJ,Kang CM

更新日期：2021-03-01 00:00:00

abstract：:Cytidine/uridine monophosphate kinase 2 (CMPK2) is a thymidylate kinase and in mammals is known to be involved in mitochondrial DNA (mtDNA) synthesis and antiviral immunity. However, very little is known about the function of CMPK2 in fish. With an aim to elucidate the antimicrobial mechanism of CMPK2 in fish, we in t...

authors： Feng C,Tang Y,Liu X,Zhou Z

更新日期：2021-03-01 00:00:00

abstract：ABSTRACT:A 19-year-old woman presented with a primary mediastinal B-cell lymphoma invading the superior vena cava with associated thrombosis of the left brachiocephalic and subclavian vein. She underwent thrombolysis followed by chemotherapy. The midtreatment 18F-FDG PET/CT demonstrated important regression of the prim...

authors： Huot Daneault A,Le Blanc R,Voyer N,Turcotte É,Rousseau E

更新日期：2021-03-01 00:00:00

abstract：INTRODUCTION:Adolescents are using e-cigarettes at high rates and there is limited information on how to help them quit. We aimed to inform e-cigarette cessation interventions by understanding why adolescents use and dislike e-cigarettes and their quit experiences. METHODS:Six focus groups with current users (i.e., pa...

authors： Kong G,Bold KW,Cavallo DA,Davis DR,Jackson A,Krishnan-Sarin S

更新日期：2021-03-01 00:00:00

abstract：:Research has shown that metacognitions are associated with addictive behaviors. This study aimed to evaluate the psychometric properties (i.e., factor structure, reliability, and predictive validity) of the Persian Metacognitions about Smartphone Use Questionnaire (Persian MSUQ). A community sample of 618 participants...

authors： Akbari M,Zamani E,Fioravanti G,Casale S

更新日期：2021-03-01 00:00:00

abstract：:Lipids are hydrophobic metabolites implicated in tea flavor quality. Understanding their transformations during tea manufacture is of particular interest. To date, the detailed lipid composition and variations during green tea manufacture are largely unknown. Herein, we performed a comprehensive characterization of th...

authors： Li J,Hua J,Yuan H,Deng Y,Zhou Q,Yang Y,Dong C,Zeng J,Jiang Y

更新日期：2021-03-01 00:00:00

abstract：:The production of low potassium vegetables arose out of the dietary needs of patients with renal dysfunction. Attempts have been made to reduce potassium content in vegetables and fruits; however, induced potassium deficiency has often resulted in decreased yields. Here, we investigated a new method of producing low p...

authors： Son YJ,Park JE,Kim J,Yoo G,Lee TS,Nho CW

更新日期：2021-03-01 00:00:00

abstract：:2-Acetyl-1-pyrroline (2-AP) has been widely reported as a key contributor to the popcorn-like aroma of fragrant rice (Oryza sativa). To gain a greater understanding of its contribution to the aroma in both fragrant and non-fragrant rice, sensory profiling was conducted with a trained panel to examine the sensory prope...

authors： Wei X,Sun Q,Methven L,Elmore JS

更新日期：2021-03-01 00:00:00

abstract：:The aim of this study was to increase the baked flavour of low-acrylamide potato products. Strecker aldehydes and pyrazines make an important contribution to the flavour of potato products and are formed alongside acrylamide in the Maillard reaction. However, the Maillard reaction can be directed in favour of aroma fo...

authors： Kocadağlı T,Methven L,Kant A,Parker JK

更新日期：2021-03-01 00:00:00

abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Quite a few plants are in use to treat female infertility and associated problems. Availing the cues from traditional knowledge, phytochemical studies and ethnopharmacological evidences, the aphrodisiac plant Ficus religiosa (F. religiosa) is widely in use to cure infertility in women. Fo...

authors： Suriyakalaa U,Ramachandran R,Doulathunnisa JA,Aseervatham SB,Sankarganesh D,Kamalakkannan S,Kadalmani B,Angayarkanni J,Akbarsha MA,Achiraman S

更新日期：2021-03-01 00:00:00

abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Clerodendrum cyrtophyllum Turcz has been used in traditional medicine for the treatment of various diseases. In spite of its therapeutic applications, research on its toxicity and teratogenicity is still limited. AIM OF THE STUDY:The study aimed to investigate the developmental toxicity ...

authors： Nguyen TH,Nguyen PD,Quetin-Leclercq J,Muller M,Ly Huong DT,Pham HT,Kestemont P

更新日期：2021-03-01 00:00:00

abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Aristolochic acid nephropathy (AAN) is a kidney disease caused by the administration of plants containing aristolochic acids (AAs). Aristolochic acid I (AAI) is the main toxic component in AAs. Organic anion transporters (OATs) 1 and 3 mediate the renal uptake of AAI, which is related to ...

authors： Ma L,Shen Z,Hu H,Zhou H,Yu L,Jiang H,Zeng S

更新日期：2021-03-01 00:00:00

abstract：:Cardio-Oncology has blossomed as a new field in cardiovascular medicine, in large part due to new therapies, which may have cardiovascular sequelae. Despite this, anthracyclines still serve as cornerstone therapy for most pediatric cancers, several solid tumors and hematological malignancies. Cardiotoxicity is the mai...

authors： Screever EM,Meijers WC,Moslehi JJ

更新日期：2021-03-01 00:00:00

abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Inflammation caused by activated microglia is known to be associated with neurodegenerative diseases, e.g., Parkinson's disease (PD) and Alzheimer's disease (AD). Inhibiting the inflammatory process can be considered a potential strategy for the treatment of inflammation-associated diseas...

authors： Rachsee A,Chiranthanut N,Kunnaja P,Sireeratawong S,Khonsung P,Chansakaow S,Panthong A

更新日期：2021-03-01 00:00:00

abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Malignant ascites (MA) effusion is mainly caused by hepatocellular, ovarian, and breast cancer etc. It has been reported that Euphorbia kansui (EK), the root of Euphorbia kansui S.L.Liou ex S.B.Ho, possessing a therapeutic effect on MA. However, the clinical applications of EK are serious...

authors： Zhang Q,Ju YH,Zhang Y,Wang K,Zhang M,Chen PD,Yao WF,Tang YP,Wu JH,Zhang L

更新日期：2021-03-01 00:00:00

abstract：:Cystic fibrosis is a hereditary disease that mostly affects the sweat glands, respiratory system, digestive system, and reproductive system. Many and various types of mutations have been reported in CFTR in different ethnicities and countries/regions. Analysis of CFTR gene rearrangements is recommended in patients wit...

authors： Duz MB,Ozyavuz Cubuk P

更新日期：2021-03-01 00:00:00

abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Synadenium grantii Hook. f., popularly known as "janaúba" or "leiterinha", is used in the folk medicine to treat gastric disorders, some types of neoplasias and inflammatory diseases. AIM OF THE STUDY:The aim of this study was to show the anti-inflammatory activity of the methanol extrac...

authors： de Souza JA,Patel YBK,Grockoski HA,Nunes R,Ramos SA,Pastor MVD,Stoeberl LC,Campos A,Cechinel Filho V,Santin JR,Quintão NLM

更新日期：2021-03-01 00:00:00

abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Gardenia jasminoides J. Ellis (Fructus Gardenia) is a traditional Chinese medicine with diverse pharmacological functions, such as anti-inflammation, anti-depression, as well as improvement of cognition and ischemia brain injury. GJ-4 is a natural extract from Gardenia jasminoides J. Elli...

authors： Liu H,Zhang Z,Zang C,Wang L,Yang H,Sheng C,Shang J,Zhao Z,Yuan F,Yu Y,Yao X,Bao X,Zhang D

更新日期：2021-03-01 00:00:00